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Prof. Artur Mucha, DSc, PhD, Eng
Email: artur.mucha@pwr.edu.pl
Unit: Faculty of Chemistry » Department of Bioorganic Chemistry
Wybrzeże Wyspiańskiego 29, 50-371 Wrocław
building A-2, room 304
phone +48 71 320 3446
Office hours
- Monday 13.00-15.00
- Wednesday 11.00-13.00
Research fields
- Organophosphorus compounds; enzyme inhibitors.
Recent papers
2017
- Ntatsopoulos V., Vassiliou S., Macegoniuk K., Berlicki Ł., Mucha A., Novel organophosphorus scaffolds of urease inhibitors obtained by substitution of Morita-Baylis-Hillman adducts with phosphorus nucleophiles. Eur. J. Med. Chem. 2017, 133, 107-120.
2016
- Węglarz-Tomczak E., Berlicki Ł., Pawełczak M., Nocek B., Joachimiak A., Mucha, A., A structural insight into the P1-S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases. Eur. J. Med. Chem. 2016, 117, 187-196.
2014
- Vassiliou S., Węglarz-Tomczak E., Berlicki Ł., Pawełczak M., Nocek B., Mulligan R., Joachimiak A., Mucha, A., Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J. Med. Chem. 2014, 57, 8140-8151.
2011
- Mucha A., Synthesis and modifications of phosphinic dipeptide analogues. Molecules 2012, 17, 13530-13568.
- Mucha A., Kafarski P., Berlicki Ł., Remarkable potential of the alpha-aminophosphonate/phosphinate structural motif in medicinal chemistry. J. Med. Chem. 2011, 54, 5955-5980.