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Faculty of Computer Science and Management

Prof. Artur Mucha, DSc, PhD, Eng

Email: artur.mucha@pwr.edu.pl

Unit: Faculty of Chemistry » Department of Bioorganic Chemistry

Wybrzeże Wyspiańskiego 29, 50-371 Wrocław
building A-2, room 304
phone +48 71 320 3446

Office hours

  • Monday 13.00-15.00
  • Wednesday 11.00-13.00

Research fields

  • Organophosphorus compounds; enzyme inhibitors.

Recent papers

2017

  • Ntatsopoulos V., Vassiliou S., Macegoniuk K., Berlicki Ł., Mucha A., Novel organophosphorus scaffolds of urease inhibitors obtained by substitution of Morita-Baylis-Hillman adducts with phosphorus nucleophiles. Eur. J. Med. Chem. 2017, 133, 107-120.

2016

  • Węglarz-Tomczak E., Berlicki Ł., Pawełczak M., Nocek B., Joachimiak A., Mucha, A., A structural insight into the P1-S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases. Eur. J. Med. Chem. 2016, 117, 187-196.

2014

  • Vassiliou S., Węglarz-Tomczak E., Berlicki Ł., Pawełczak M., Nocek B., Mulligan R., Joachimiak A., Mucha, A., Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J. Med. Chem. 2014, 57, 8140-8151.

2011

  • Mucha A., Synthesis and modifications of phosphinic dipeptide analogues. Molecules 2012, 17, 13530-13568.
  • Mucha A., Kafarski P., Berlicki Ł., Remarkable potential of the alpha-aminophosphonate/phosphinate structural motif in medicinal chemistry. J. Med. Chem. 2011, 54, 5955-5980.

Papers in DONA database

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