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Elżbieta Wieczorek, DSc, PhD, Eng
Email: elzbieta.wieczorek@pwr.edu.pl
Unit: Faculty of Chemistry » Department of Biochemistry, Molecular Biology and Biotechnology
ul. Gdańska 7/9, 50-344 Wrocław
building F-4, room C-16
phone +48 71 320 6226
Research interest
- Understanding the structure, function and post-translational modifications of human transthyretin;
- Studying the structural changes and changes in physicochemical properties of transthyretin that occur in the process leading to amyloid formation.
- Understanding the role of human transthyretin in bio-mineralization and in response to cellular stress.
- To studying the relationship between structural changes in transthyretin and the disease processes in which they occur.
Recent papers
Wieczorek E, Wygralak Z, Kędracka-Krok S, Bezara P, Bystranowska D, Dobryszycki P, Ożyhar A. Deep blue autofluorescence reflects the oxidation state of human transthyretin. Redox Biol. 2022 Aug 9;56:102434. doi: 10.1016/j.redox.2022.102434. Epub ahead of print. PMID: 35987087; PMCID: PMC9411673.
Wieczorek, E.; Ożyhar, A. Transthyretin: From structural stability to osteoarticular and cardiovascular diseases. Cells 2021, 10, doi:10.3390/cells10071768. PMID: 34359938
Wieczorek, E.; Bezara, P.; Ożyhar, A. Deep blue autofluorescence reveals the instability of human transthyretin. Int. J. Biol. Macromol. 2021, 191, 492–499, doi:10.1016/j.ijbiomac.2021.09.107. PMID: 34562536
Wieczorek, E.; Kędracka-Krok, S.; Bystranowska, D.; Ptak, M.; Wiak, K.; Wygralak, Z.; Jankowska, U.; Ożyhar, A. Destabilisation of the structure of transthyretin is driven by Ca2+. Int. J. Biol. Macromol. 2021, 166, 409–423, doi:10.1016/j.ijbiomac.2020.10.199. PMID: 33129902
Wieczorek, E.; Chitruń, A.; Ożyhar, A. Destabilised human transthyretin shapes the morphology of calcium carbonate crystals. Biochim. Biophys. Acta - Gen. Subj. 2019, 1863, 313–324, doi:10.1016/j.bbagen.2018.10.017. PMID: 30394286
Wieczorek, E.; Kędracka–Krok, S.; Sołtys, K.; Jankowska, U.; Hołubowicz, R.; Seliga, J.; Ożyhar, A. Is Transthyretin a Regulator of Ubc9 SUMOylation? PLoS ONE 2016, 11, e0160536. PMID: 27501389