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Wioletta Rut-Schedlok, DSc, PhD, Eng
Email: wioletta.rut@pwr.edu.pl
Unit: Faculty of Chemistry » Department of Chemical Biology and Bioimaging
Wybrzeże Wyspiańskiego 29, 50-371 Wrocław
building A-2, room 305 C
phone +48 71 320 2455
Research fields
- Proteolytic enzymes; substrate specificity; activity-based probe; combinatorial chemistry.
Recent papers
2017
- Rut W., Zhang L., Kasperkiewicz P., Poręba M., Hilgenfeld R., Drąg M., Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease, Antiviral Research, 2017, 139, 88-94.
- Poręba M., Szalek A., Rut W., Kasperkiewicz P., Rutkowska-Włodarczyk I., Snipas S. J., Itoh Y. Turk D., Turk B., Overall Ch., Kaczmarek L., Salvesen G. S., Drąg M., Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families, Scientific Reports, 2017, 7, 1-13.
2016
- Poreba M., Solberg R., Rut W., Lunde N.N., Kasperkiewicz P., Snipas S.J., Mihelic M., Turk D., Turk B., Salvesen G.S., Drag M., Counter selection substrate library strategy for developing specific protease substrates and probes, Cell Chemical Biology, 2016, 23(8), 1023-35.
- Rut W., Drąg M., Human 20S proteasome activity toward fluorogenic peptides of various chain lengths, Biological Chemistry, 2016, 397(9), 921-6.
2015
- Rut W., Kasperkiewicz P., Byzia A., Poreba M., Groborz K., Drag M., Recent advances and concepts in substrate specificity determination of proteases using tailored libraries of fluorogenic substrates with unnatural amino acids, Biological Chemistry, 2015, 396(4), 329-37.